| Acronym | Definition |
|---|
| ESN | Erasmus Student Network (Europe) |
| ESN | Electronic Serial Number |
| ESN | Entreprise de Services du Numérique (French: Digital Service Company) |
| ESN | Equipment Serial Number (cellular) |
| ESN | Enterprise Social Networking |
| ESN | Engine Serial Number |
| ESN | Engineering Services Network |
| ESN | Emergency Service Number |
| ESN | European Social Network |
| ESN | Electronic Security Number |
| ESN | Eclipse Security Network |
| ESN | Enterprise Service Network |
| ESN | Energy Sciences Network (Sprint) |
| ESN | Educationally Sub-Normal (UK) |
| ESN | Enterprise Storage Network |
| ESN | Electronic Switched Network |
| ESN | Eclipse Security Network (electronics) |
| ESN | European Securities Network |
| ESN | Entente Sportive Nanterre (French sports club) |
| ESN | Epilepsy Specialist Nurse |
| ESN | Entertainment and Sports Network |
| ESN | Euro Style Nymphing (fishing rod) |
| ESN | Elysian Space Navy (Honor Harrington science fiction novels) |
| ESN | Entente Sportive Nogentaise (French sports club) |
| ESN | English-Speaking Nation |
| ESN | Earthstewards Network |
| ESN | Enterprise Services for NFuse (software) |
| ESN | European Services Network (industry federation) |
| ESN | Étoile Sportive de Nouaillé (French sports club) |
| ESN | Étoile Sportive Nouzilly (French sports club) |
| ESN | Employed Student Nurse (Canada) |
| ESN | Electronic Signage Network |
| ESN | Essential Services Node |
| ESN | Electronic Sports Network |
| ESN | EOSDIS Science Network |
| ESN | Electrical Symbol Number |
| ESN | Eric Sookie Nookie (True Blood fan term) |